Seizures beget seizures – Nature Reviews Neuroscience

Absence seizures, a prominent manifestation of generalized epilepsy, are characterized by excessive interhemispheric synchrony, especially between the frontoparietal cortices. Unmanaged or intractable absence seizures in people with generalized epilepsy can lead to an increase in seizure frequency over time, so the development of therapies that prevent this is a priority. The mechanisms that underlie the increase in seizure burden are incompletely understood. In this study, Knowles et al. show that recurrent absence seizures in rodents increase myelination in the seizure circuit, and that this results in hypersynchrony between affected brain areas.

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