Psychiatric Comorbidities in Epilepsy

Psychiatric Comorbidities in Epilepsy
Carlos Arteaga Rodríguez1,2, Mariana Menine Kubis3, Carlos Bruno Teixeira Arteaga4, and Otto Jesus Hernandez Fustes5
1Department of Medicine, Positivo University, Curitiba, Brazil
2Municipal Health Department, Curitiba, Brazil
3Psychiatric Center, Municipal Health Department, Curitibal, Brazil
4Department of Medicine, University of Ribeirão Preto, Ribeirão Preto, Brazil
5Neurology Service, Clinics Complex Hospital at Federal University of Paraná, Curitiba, Brazil
Corresponding Author:
Otto Jesus Hernandez Fustes ,Tel: +55-41.33387717, Fax: +55-41.33388885, Email:
Received: November 18, 2021; Revised: December 16, 2021   Accepted: January 25, 2022.  Published online: June 30, 2022.
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Background and Purpose: Psychiatric comorbidities (PC) occur more frequently in patients with epilepsy than in the general population. To determine the main PC associated with epilepsy and its association with demographic data and clinical features of epilepsy.

Methods: A retrospective study was carried out on patients with epilepsy at the Medical Specialties Center of the Municipal Health Department. Demographic data, crisis onset, time range of seizures evolution, type of epileptic seizures, types of epilepsy, etiology, brain injury, topographic location, hemispheric location, type of antiepileptic drugs (AEDs), use of monotherapy or polytherapy, control of epileptic seizures and the PC were recorded.

Results: One hundred forty adult patients were studied 51.4% male, mean age 44.9 years, time of evolution of the crises was 14 years, focal crisis 88.6%, mesial temporal sclerosis 42%, controlled 92.4%, monotherapy 66.1%, and the most used AEDs were carbamazepine (33.1%), valproic acid (28.2%), and phenobarbital (10.4%). The PC present in 67.1% of the patients was depression (22.8%), anxiety disorder (AD) (17.8%), psychosis (10%), dementia (9.2%) and bipolar affective disorder (BAD) (8.5%). The relationship between PC and crisis control was significant (pConclusions: Schooling was lower than that reported in the general population in Brazil, and we found a low rate of unemployment or retirement. Epilepsy is associated with PC, the most frequent being depression, AD, psychosis, dementia and BAD. The absence of a relationship between depression and brain damage; anxiety disorder with education, types of epilepsy and etiology; psychosis with sex and time of epilepsy evolution were significant.
Key words:
Depression | Epilepsy | Mental health | Psychiatric comorbidities | Seizures

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